Hypericin and hyperforin mobilise psychic energy and soothe agitated or anxious states; hypericin stabilises mood. That's why St John's wort is recommended for melancholia, apathy, blue moods, the sense of despondency and the lack of self-confidence. Usage precaution: Risk of interaction with other medications. Combining St John's wort with other medications can diminish their efficacy. Conversely, suddenly interrupting a course of treatment with St John's wort can increase the toxicity of the other medications. Consult your doctor for details.